Founded in 1974, Pickaway-Ross offers 20 high school tech-prep programs to students from 10 high schools in Ross and Pickaway counties. High school students attend Pickaway-Ross for their junior and senior years and can earn a Career Passport from Pickaway-Ross in addition to a diploma from their home schools. Six hundred students attend Pickaway-Ross's main campus and 1,500 students attend off-campus (or satellite) programs housed in affiliated high schools.
School districts affiliated with Pickaway-Ross are Circleville, Logan Elm and Westfall in Pickaway County and Adena, Chillicothe, Huntington, Paint Valley, Southeastern, Unioto and Zane Trace in Ross County.